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The association of wild-type BRD4 ET with DNA was largely unaffected in the presence of ASXL1 EBM in EMSA, confirming that the two binding sites located on the opposite sides of BRD4 ET do not overlap (Fig

Mohamed MM, Sabet S, Peng DF, Nouh MA, El-Shinawi M, El-Rifai W

In a later study, similar sensors were made to image Rac1 activity during sLTP in hippocampal neurons, and it was found that Rac1 was also required for the transient and sustained spine enlargement ( Rho GTPases in Synaptic Plasticity In addition to affecting spine properties, many studies have shown that Rho GTPases are potent regulators of synaptic transmission and plasticity (Figure 2)